Studies on Synthetic Analgesics. VIII
نویسندگان
چکیده
منابع مشابه
Animal experimentation in studying addiction to the newer synthetic analgesics.
HE term addiction, when applied to the syndrome resulting from T the prolonged use of morphine and its congeners in man, by coinmon usage involves three principal components, psychic dependence, physical dependence, and acquired toleranee. In view of the fact that the newer synthetic analgesics produce pharmacological effects, many of which are qualitatively similar to those of morphine and its...
متن کاملStudies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations.
We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...
متن کاملAn update on analgesics.
Recent introduction of new analgesics into the clinic is best described as a slow process with activity classified into two main areas: improving analgesic efficacy/potency and reducing side-effect profile. This review article describes some of the recent advances with an emphasis on use in the acute setting. In this respect, opioids continue to be the mainstay (but not the only) analgesic and ...
متن کاملX-ray studies on phospholipid bilayers. VIII. Interactions with chlorpromazine.HCl.
Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine.HCl (CPZ.HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ra...
متن کاملStudies on the Purification and Characterization of Human Factor VIII
The purified factor VIII has been found to be a macromolecular glycoprotein with a major subunit of 240,000, as shown by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis. Carbohydrate analysis of factor VIII gave values of 1% sialic acid, 2.8% hexosamine, and 1-2% hexose (mannose, galactose, and fucose). The lipid content was found to be less than 5% of the protein content, and i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1955
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.75.6_658